Zoeken
Zoeken kan via de modus 'eenvoudig zoeken' (één veld) of uitgebreid via 'geavanceerd zoeken' (meerdere velden). Zo kan je bv. zoeken op een combinatie van een auteursnaam (auteur), een jaartal (jaar) en een documenttype.
Boekenmand
Nuttige resultaten kan je aanvinken en toevoegen aan een mandje. De inhoud hiervan kan je exporteren of afdrukken (naar bv. PDF).
RSS
Op de hoogte blijven van nieuw toegevoegde publicaties binnen uw interessegebied? Dit kan door een RSS-feed (?) te maken van jouw zoekopdracht.
nieuwe zoekopdracht
| one publication added to basket [347192] |
Association between Chromosome 4 and mercury accumulation in muscle of the three‐spined stickleback (Gasterosteus aculeatus)
Calboli, F.C.F.; Delahaut, V.; Deflem, I.; Hablützel, P.I.; Hellemans, B.; Kordas, A.; Raeymaekers, J.A.M.; Bervoets, L.; De Boeck, G.; Volckaert, F. (2021). Association between Chromosome 4 and mercury accumulation in muscle of the three‐spined stickleback (Gasterosteus aculeatus). Evol. Appl. 14(10): 2553-2567. https://dx.doi.org/10.1111/eva.13298
In: Evolutionary Applications. Blackwell: Oxford. ISSN 1752-4571; e-ISSN 1752-4571
|   |
| Trefwoord |
Gasterosteus aculeatus Linnaeus, 1758 [WoRMS]
|
| Author keywords |
adaptation, environment, mercury, next generation sequencing, pollution, selection, three-spined stickleback |
| Auteurs | | Top |
- Calboli, F.C.F.
- Delahaut, V.
- Deflem, I.
- Hablützel, P.I.
|
- Hellemans, B.
- Kordas, A.
- Raeymaekers, J.A.M.
|
- Bervoets, L.
- De Boeck, G.
- Volckaert, F.
|
| Abstract |
Anthropogenic stressors, such as pollutants, act as selective factors that can leave measurable changes in allele frequencies in the genome. Metals are of particular concern among pollutants, because of interference with vital biological pathways. We use the three-spined stickleback as a model for adaptation to mercury pollution in natural populations. We collected sticklebacks from 21 locations in Flanders (Belgium), measured the accumulated levels of mercury in the skeletal muscle tissue, and genotyped the fish by sequencing (GBS). The spread of muscle mercury content across locations was considerable, ranging from 21.5 to 327 ng/g dry weight (DW). We then conducted a genome-wide association study (GWAS) between 28,450 single nucleotide polymorphisms (SNPs) and the accumulated levels of mercury, using different approaches. Based on a linear mixed model analysis, the GWAS yielded multiple hits with a single top hit on Chromosome 4, with eight more SNPs suggestive of association. A second approach, a latent factor mixed model analysis, highlighted one single SNP on Chromosome 11. Finally, an outlier test identified one additional SNP on Chromosome 4 that appeared under selection. Out of all ten SNPs we identified as associated with mercury in muscle, three SNPs all located on Chromosome 4 and positioned within a 2.5 kb distance of an annotated gene. Based on these results and the genome coverage of our SNPs, we conclude that the selective effect of mercury pollution in Flanders causes a significant association with at least one locus on Chromosome 4 in three-spined stickleback. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
