Zoeken
Zoeken kan via de modus 'eenvoudig zoeken' (één veld) of uitgebreid via 'geavanceerd zoeken' (meerdere velden). Zo kan je bv. zoeken op een combinatie van een auteursnaam (auteur), een jaartal (jaar) en een documenttype.
Boekenmand
Nuttige resultaten kan je aanvinken en toevoegen aan een mandje. De inhoud hiervan kan je exporteren of afdrukken (naar bv. PDF).
RSS
Op de hoogte blijven van nieuw toegevoegde publicaties binnen uw interessegebied? Dit kan door een RSS-feed (?) te maken van jouw zoekopdracht.
nieuwe zoekopdracht
| one publication added to basket [280654] |
Rh protein expression in branchial neuroepithelial cells, and the role of ammonia in ventilatory control in fish
Zhang, L.; Nawata, C.M.; De Boeck, G.; Wood, C.M. (2015). Rh protein expression in branchial neuroepithelial cells, and the role of ammonia in ventilatory control in fish. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 186: 39-51. https://dx.doi.org/10.1016/j.cbpa.2014.10.004
In: Comparative Biochemistry and Physiology. Part A. Molecular and Integrative Physiology. Elsevier: New York. ISSN 1095-6433; e-ISSN 1531-4332
|  |
| Trefwoorden |
Elasmobranchii [WoRMS]; Teleostei [WoRMS]
Marien/Kust |
| Author keywords |
Ammonia; Teleost fish; Elasmobranchs; Chemoreceptors; Rhesusglycoproteins; Neuroepithelial cells; Ventilation; Brain; 1st gill arch;Serotonin |
| Auteurs | | Top |
- Zhang, L.
- Nawata, C.M.
- De Boeck, G.
- Wood, C.M.
|
|
|
| Abstract |
Bill Milsom has made seminal contributions to our understanding of ventilatory control in a wide range of vertebrates. Teleosts are particularly interesting, because they produce a 3rd, potentially toxic respiratory gas (ammonia) in large amounts. Fish are well known to hyperventilate under high environmental ammonia (HEA), but only recently has the potential role of ammonia in normal ventilatory control been investigated. It is now clear that ammonia can act directly as a ventilatory stimulant in trout, independent of its effects on acid–base balance. Even in ureotelic dogfish sharks, acute elevations in ammonia cause increases in ventilation. Peripherally, the detection of elevated ammonia resides in gill arches I and II in trout, and in vitro, neuroepithelial cells (NECs) from these arches are sensitive to ammonia, responding with elevations in intracellular Ca2 + ([Ca2 +]i). Centrally, hyperventilatory responses to ammonia correlate more closely with concentrations of ammonia in the brain than in plasma or CSF. After chronic HEA exposure, ventilatory responsiveness to ammonia is lost, associated with both an attenuation of the [Ca2 +]i response in NECs, and the absence of elevation in brain ammonia concentration. Chronic exposure to HEA also causes increases in the mRNA expression of several Rh proteins (ammonia-conductive channels) in both brain and gills. “Single cell” PCR techniques have been used to isolate the individual responses of NECs versus other gill cell types. We suggest several circumstances (post-feeding, post-exercise) where the role of ammonia as a ventilatory stimulant may have adaptive benefits for O2 uptake in fish. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
