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Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.

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Testosterone metabolism modulation in Neomysis integer: a biomarker for endocrine disruption Poelmans, S.; Verslycke, T.; Noppe, H.; Van Hoof, N.; De Brabander, H.; Janssen, C.R. (2005). Testosterone metabolism modulation in Neomysis integer: a biomarker for endocrine disruption, in: Mees, J. et al. VLIZ Young Scientists' Day, Brugge, Belgium 25 February 2005: book of abstracts. VLIZ Special Publication, 20: pp. 52 In: Mees, J.; Seys, J. (Ed.) (2005). VLIZ Young Scientists' Day, Brugge, Belgium 25 February 2005: book of abstracts. VLIZ Special Publication, 20. Vlaams Instituut voor de Zee (VLIZ): Oostende. X, 129 pp., meer In: VLIZ Special Publication. Vlaams Instituut voor de Zee (VLIZ): Oostende. ISSN 1377-0950, meer

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Beschikbaar in	Auteurs
VLIZ: Open access 375262 [ download pdf ]
Documenttype: Samenvatting

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Trefwoorden

Neomysis integer (Leach, 1814) [WoRMS] Marien/Kust

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Auteurs		Top
Poelmans, S., meer Verslycke, T., meer Noppe, H., meer	Van Hoof, N. De Brabander, H., meer Janssen, C.R., meer

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Abstract

Cytochrome P450-dependent monooxygenases (P450s) are important enzymes in the metabolic system and are involved in the regulation of hormone synthesis and in the detoxification and/or activation of xenobiotics. P450s are found in virtually all aerobic organisms, from invertebrates to vertebrates. A number of endocrine disruptors are suspected of exerting their effects through disruption of normal CYP function.Consequently, alterations of steroid hormone metabolism by CYP modulators can be an important tool to study potential effects of endocrine disruptors in invertebrates. The invertebrate mysid Neomysis integer (Crustacea; Mysidacea) was used to asses changes in the testosterone metabolism after a short-term exposure to four environmentally relevant CYP modulators. N. integer was exposed to sublethal concentrations of different endocrine disruptors, tributyltin (TBT), nonylphenol (NP) and phenobarbital (PB), and subsequently to testosterone. Identification and quantification of the steroid components was performed using liquid chromatography coupled with multiple mass spectrometry. The effects of the different CYP modulators on phase I and phase II testosterone metabolism are discussed and compared. We conclude that the testosterone metabolism of N. integer is a sensitive endpoint to detect endocrine disruption of chemicals after a short- term exposure.

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