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Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.

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The brittle star genome illuminates the genetic basis of animal appendage regeneration Parey, E.; Ortega-Martinez, O.; Delroisse, J.; Piovani, L.; Czarkwiani, A.; Dylus, D.; Arya, S.; Dupont, S.; Thorndyke, M.; Larsson, T.; Johannesson, K.; Buckley, K.M.; Martinez, P.; Oliveri, P.; Marlétaz, F. (2024). The brittle star genome illuminates the genetic basis of animal appendage regeneration. Nature Ecology & Evolution 8(8): 1505-1521. https://dx.doi.org/10.1038/s41559-024-02456-y In: Nature Ecology & Evolution. Springer Nature. ISSN 2397-334X, meer Is gerelateerd aan: Loubet-Senear, K.; Srivastava, M. (2024). Brittle star genome provides information on the evolution of regeneration. Nature Ecology & Evolution 8(8): 1385-1386. https://dx.doi.org/10.1038/s41559-024-02459-9, meer

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Beschikbaar in	Auteurs
VLIZ: Open access 408506 [ download pdf ]

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Trefwoorden

Amphiura filiformis (O.F. Müller, 1776) [WoRMS] Marien/Kust

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Auteurs		Top
Parey, E. Ortega-Martinez, O. Delroisse, J., meer Piovani, L. Czarkwiani, A.	Dylus, D. Arya, S. Dupont, S., meer Thorndyke, M., meer Larsson, T.	Johannesson, K. Buckley, K.M. Martinez, P. Oliveri, P. Marlétaz, F.

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Abstract

Species within nearly all extant animal lineages are capable of regenerating body parts. However, it remains unclear whether the gene expression programme controlling regeneration is evolutionarily conserved. Brittle stars are a species-rich class of echinoderms with outstanding regenerative abilities, but investigations into the genetic bases of regeneration in this group have been hindered by the limited genomic resources. Here we report a chromosome-scale genome assembly for the brittle star Amphiura filiformis. We show that the brittle star genome is the most rearranged among echinoderms sequenced so far, featuring a reorganized Hox cluster reminiscent of the rearrangements observed in sea urchins. In addition, we performed an extensive profiling of gene expression during brittle star adult arm regeneration and identified sequential waves of gene expression governing wound healing, proliferation and differentiation. We conducted comparative transcriptomic analyses with other invertebrate and vertebrate models for appendage regeneration and uncovered hundreds of genes with conserved expression dynamics, particularly during the proliferative phase of regeneration. Our findings emphasize the crucial importance of echinoderms to detect long-range expression conservation between vertebrates and classical invertebrate regeneration model systems.

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