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| one publication added to basket [293599] |
Impact of high hydrostatic pressure on bacterial proteostasis
In: Biophysical Chemistry. ELSEVIER SCIENCE BV: Amsterdam. ISSN 0301-4622; e-ISSN 1873-4200, meer
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| Trefwoorden |
Escherichia coli Castellani & Chalmers, 1919 [WoRMS]
Marien/Kust |
| Author keywords |
High hydrostatic pressure; E. coli; Piezophiles; Protein translation;Protein aggregates; Resistance development |
| Auteurs | | Top |
- Gayan, E., meer
- Govers, S.K.
- Aertsen, A., meer
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| Abstract |
High hydrostatic pressure (HHP) is an important factor that limits microbial growth in deep-sea ecosystems to specifically adapted piezophiles. Furthermore, HHP treatment is used as a novel food preservation technique because of its ability to inactivate pathogenic and spoilage bacteria while minimizing the loss of food quality. Disruption of protein homeostasis (i.e. proteostasis) as a result of HHP-induced conformational changes in ribosomes and proteins has been considered as one of the limiting factors for both microbial growth and survival under HHP conditions. This work therefore reviews the effects of sublethal (<= 100 MPa) and lethal (>100 MPa) pressures on protein synthesis, structure, and functionality in bacteria. Furthermore, current understanding on the mechanisms adopted by piezophiles to maintain proteostasis in HHP environments and responses developed by atmospheric-adapted bacteria to protect or restore proteostasis after HHP exposure are discussed. |
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