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Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.

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Divergent mechanisms regulate conserved cardiopharyngeal development and gene expression in distantly related ascidians Stolfi, A.; Lowe, E.K.; Racioppi, C.; Ristoratore, F.; Brown, C.T.; Swalla, B.J.; Christiaen, L. (2014). Divergent mechanisms regulate conserved cardiopharyngeal development and gene expression in distantly related ascidians. eLIFE 3: e03728. https://dx.doi.org/10.7554/eLife.03728 In: eLIFE. eLife Sciences Publications: Cambridge. e-ISSN 2050-084X, meer

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Beschikbaar in	Auteurs
VLIZ: Open access 307056 [ download pdf ]

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Trefwoorden

Marine Sciences Marine Sciences > Marine Genomics Scientific Community Scientific Publication Marien/Kust

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Association of European marine biological laboratories, meer

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Stolfi, A. Lowe, E.K. Racioppi, C. Ristoratore, F.	Brown, C.T. Swalla, B.J. Christiaen, L.

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Abstract

Ascidians present a striking dichotomy between conserved phenotypes and divergent genomes: embryonic cell lineages and gene expression patterns are conserved between distantly related species. Much research has focused on Ciona or Halocynthia spp. but development in other ascidians remains poorly characterized. In this study, we surveyed the multipotent myogenic B7.5 lineage in Molgula spp. Comparisons to the homologous lineage in Ciona revealed identical cell division and fate specification events that result in segregation of larval, cardiac, and pharyngeal muscle progenitors. Moreover, the expression patterns of key regulators are conserved, but cross-species transgenic assays uncovered incompatibility, or 'unintelligibility', of orthologous cis-regulatory sequences between Molgula and Ciona. These sequences drive identical expression patterns that are not recapitulated in cross-species assays. We show that this unintelligibility is likely due to changes in both cis- and trans-acting elements, hinting at widespread and frequent turnover of regulatory mechanisms underlying otherwise conserved aspects of ascidian embryogenesis.

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