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| one publication added to basket [199757] |
Gene transcription profiles, global DNA methylation and potential transgenerational epigenetic effects related to Zn exposure history in Daphnia magna
Vandegehuchte, M.B.; De Coninck, D.; Vandenbrouck, T.; De Coen, W.M.; Janssen, C.R. (2010). Gene transcription profiles, global DNA methylation and potential transgenerational epigenetic effects related to Zn exposure history in Daphnia magna. Environ. Pollut. 158(10): 3323-3329. dx.doi.org/10.1016/j.envpol.2010.07.023
In: Environmental Pollution. Elsevier: Barking. ISSN 0269-7491; e-ISSN 1873-6424, meer
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| Author keywords |
Ecotoxicology; Hypomethylation; Microarray; Multigeneration; Zinc |
| Auteurs | | Top |
- Vandegehuchte, M.B., meer
- De Coninck, D., meer
- Vandenbrouck, T., meer
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| Abstract |
A reduced level of DNA methylation has recently been described in both Zn-exposed and non-exposed offspring of Daphnia magna exposed to Zn. The hypothesis examined in this study is that DNA hypomethylation has an effect on gene transcription. A second hypothesis is that accumulative epigenetic effects can affect gene transcription in non-exposed offspring from parents with an exposure history of more than one generation. Transcriptional gene regulation was studied with a cDNA microarray. In the exposed and non-exposed hypomethylated daphnids, a large proportion of common genes were similarly up- or down-regulated, indicating a possible effect of the DNA hypomethylation. Two of these genes can be mechanistically involved in DNA methylation reduction. The similar transcriptional regulation of two and three genes in the F0 and F1 exposed daphnids on one hand and their non-exposed offspring on the other hand, could be the result of a one-generation temporary transgenerational epigenetic effect, which was not accumulative.Zn-induced DNA hypomethylation is related to gene transcription in Daphnia magna and Zn exposure potentially induced limited temporary transgenerational effects on gene transcription. |
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