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First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself
Skazina, M.; Odintsova, N.; Maiorova, M.; Ivanova, A.; Väinölä, R.; Strelkov, P. (2021). First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself. NPG Scientific Reports 11(1): 5809. https://dx.doi.org/10.1038/s41598-021-85098-5
In: Scientific Reports (Nature Publishing Group). Nature Publishing Group: London. ISSN 2045-2322; e-ISSN 2045-2322, meer
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| Auteurs | | Top |
- Skazina, M.
- Odintsova, N.
- Maiorova, M.
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- Ivanova, A.
- Väinölä, R., meer
- Strelkov, P.
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| Abstract |
Two lineages of bivalve transmissible neoplasia (BTN), BTN1 and BTN2, are known in blue mussels Mytilus. Both lineages derive from the Pacific mussel M. trossulus and are identified primarily by their unique genotypes of the nuclear gene EF1α. BTN1 is found in populations of M. trossulus from the Northeast Pacific, while BTN2 has been detected in populations of other Mytilus species worldwide but not in M. trossulus itself. Here we examined M. trossulus from the Sea of Japan (Northwest Pacific) for the presence of BTN. Using hemocytology and flow cytometry of the hemolymph, we confirmed the presence of disseminated neoplasia in our specimens. Cancerous mussels possessed the BTN2 EF1α genotype and two mitochondrial haplotypes with different recombinant control regions, similar to that of common BTN2 lineages. This is the first report of BTN2 in its original host species M. trossulus. A comparison of all available BTN and M. trossulus COI sequences suggests a common and recent origin of BTN2 diversity in populations of M. trossulus outside the Northeast Pacific, possibly in the Northwest Pacific. |
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