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Effect of supercritical carbon dioxide extraction parameters on the biological activities and metabolites present in extracts from Arthrospira platensis
Esquivel-Hernandez, D.A.; Rodriguez-Rodriguez, J.; Cuéllar-Bermúdez, S.P.; Garcia-Perez, J.S.; Mancera-Andrade, E.I.; Núñez-Echevarría, J.E.; Ontiveros-Valencia, A.; Rostro-Alanis, M.; Garcia-Garcia, R.M.; Torres, J.A.; Chen, W.N.; Parra-Saldivar, R. (2017). Effect of supercritical carbon dioxide extraction parameters on the biological activities and metabolites present in extracts from Arthrospira platensis. Mar. Drugs 15(6): 174. https://dx.doi.org/10.3390/md15060174
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397; e-ISSN 1660-3397, meer
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| Trefwoorden |
Arthrospira platensis Gomont, 1892 [WoRMS]
Marien/Kust |
| Author keywords |
Arthrospira platensis; supercritical fluid extraction; antioxidants;antimicrobials; bioactive compounds; nutraceuticals; -linolenic acid;tocopherol; -carotene; riboflavin |
| Auteurs | | Top |
- Esquivel-Hernandez, D.A.
- Rodriguez-Rodriguez, J.
- Cuéllar-Bermúdez, S.P., meer
- Garcia-Perez, J.S.
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- Mancera-Andrade, E.I.
- Núñez-Echevarría, J.E.
- Ontiveros-Valencia, A.
- Rostro-Alanis, M.
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- Garcia-Garcia, R.M.
- Torres, J.A.
- Chen, W.N.
- Parra-Saldivar, R.
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| Abstract |
Arthrospira platensis was used to obtain functional extracts through supercritical carbon dioxide extraction (SFE-CO2). Pressure (P), temperature (T), co-solvent (CX), static extraction (SX), dispersant (Di) and dynamic extraction (DX) were evaluated as process parameters through a Plackett–Burman design. The maximum extract yield obtained was 7.48 ± 0.15% w/w. The maximum contents of bioactive metabolites in extracts were 0.69 ± 0.09 µg/g of riboflavin, 5.49 ± 0.10 µg/g of α-tocopherol, 524.46 ± 0.10 µg/g of β-carotene, 1.44 ± 0.10 µg/g of lutein and 32.11 ± 0.12 mg/g of fatty acids with 39.38% of palmitic acid, 20.63% of linoleic acid and 30.27% of γ-linolenic acid. A. platensis extracts had an antioxidant activity of 76.47 ± 0.71 µg GAE/g by Folin–Ciocalteu assay, 0.52 ± 0.02, 0.40 ± 0.01 and 1.47 ± 0.02 µmol TE/g by DPPH, FRAP and TEAC assays, respectively. These extracts showed antimicrobial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922 and Candida albicans ATCC 10231. Overall, co-solvent was the most significant factor for all measured effects (p < 0.05). Arthrospira platensis represents a sustainable source of bioactive compounds through SFE using the following extraction parameters P: 450 bar, CX: 11 g/min, SX: 15 min, DX: 25 min, T: 60 °C and Di: 35 g. |
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