Over het archief
Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.
Dit archief wordt uitgebouwd en beheerd volgens de principes van de Open Access Movement, en het daaruit ontstane Open Archives Initiative.
Basisinformatie over ‘Open Access to scholarly information'.
The predictive potential of a battery of ecotoxicological tests for human acute toxicity, as evaluated with first 50 MEIC chemicals
Calleja, M.C.; Persoone, G.; Geladi, P. (1993). The predictive potential of a battery of ecotoxicological tests for human acute toxicity, as evaluated with first 50 MEIC chemicals. ATLA. Altern. lab. anim. 21(3): 330-349
In: ATLA. Alternatives to Laboratory Animals. Fund for the Replacement of Animals in Medical Experiments: Nottingham. ISSN 0261-1929, meer
|  |
| Author keywords |
Acute toxicity; human oral lethal dose; cyst-based toxicity test; ecotoxicological test; rodent test; MEIC chemicals; battery of tests; PLS method |
| Auteurs | | Top |
- Calleja, M.C.
- Persoone, G., meer
- Geladi, P.
|
|
|
| Abstract |
The acute toxicities of the first 50 chemicals (dextropropoxyphene hydrochloride excluded) of the multicentre evaluation of in vitro cytotoxicity (MEIC) programme were determined on four aquatic invertebrates and a bacterial strain (Photobacterium phosphoreum for the Microtox(TM) test) commonly used in ecotoxicology testing. Three of the aquatic invertebrate tests consisted of cyst-based toxicity tests (Artoxkit M with Artemia salina, Streptoxkit F with Streptocephalus proboscideus, and Rotoxkit F with Brachionus calyciflorus), and the Daphnia magna test. Results of simple linear regression analyses indicated that the rodent tests (rat and/or mouse) were better than the ecotoxicological tests for predicting acute oral lethal doses in man. However, it appears that the batteries of ecotoxicological tests resulting from the partial least squares method appear to be better than the rodent tests for predicting human oral lethal doses. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
